Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria
نویسندگان
چکیده
منابع مشابه
Nephron number and renal risk in hypertension and diabetes.
It has been proposed that "nephron underdosing," i.e., a low number of nephrons at the time of birth, is linked to essential hypertension and a greater propensity to develop progressive loss of renal function after renal injury. This hypothesis was confirmed recently by examining the number of glomeruli in patients with essential hypertension. The mechanisms through which a low number of nephro...
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در این پروژه ترکیبات 3-آریل-2h-بنزو[b]-4،1-اکسازین ها از مواد اولیه تجاری مشتقات دو آمینو فنول و ?-هالو کتون های آروماتیک در مایع یونی 1-اکتیل-3-متیل ایمیدازولیوم تترا فلورو بورات([omim]bf4) سنتز شده است. این واکنش توسط باز پتاسیم کربنات محلول از طریق o-آلکیلاسیون و سپس یک واکنش آمیداسیون درون مولکولی خود بخود در مدت زمان کوتاه انجام می شود. ترکیبات 4،1-بنزوکسازین به این روش با بهره خوب تا آلی ...
15 صفحه اولNephron number, hypertension, renal disease, and renal failure.
Wendy E. Hoy,* Michael D. Hughson, John F. Bertram, Rebecca Douglas-Denton, and Kerstin Amann *Centre for Chronic Disease, University of Queensland, Brisbane, Australia; University of Mississippi Medical Center, Jackson, Mississippi; Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia; and Department of Pathology, University of Erlangen-...
متن کامل06-P014 High nephron number in betaglycan heterozygous mice
the foregut endoderm and the defective expansion of the midand hindgut at early somite stages. However, there remains unclear whether or not Sox17 is required for the subsequent development, maturation and maintenance of the endoderm derivatives such as livers and pancreas due to the early embryonic lethal of Sox17-null mutant embryos before 10.0 dpc. Recently, we noticed the neonatal lethality...
متن کاملCofilin-1 Inactivation Leads to Proteinuria – Studies in Zebrafish, Mice and Humans
BACKGROUND Podocytes are highly specialized epithelial cells on the visceral side of the glomerulus. Their interdigitating primary and secondary foot processes contain an actin based contractile apparatus that can adjust to changes in the glomerular perfusion pressure. Thus, the dynamic regulation of actin bundles in the foot processes is critical for maintenance of a well functioning glomerula...
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ژورنال
عنوان ژورنال: Translational Research
سال: 2012
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2011.10.004